HIGHLIGHTED TOPIC Biology of Physical Activity in Youth Role of the calcium-calpain pathway in cytoskeletal damage after eccentric contractions
نویسندگان
چکیده
Bao-Ting Zhang, Simon S. Yeung, David G. Allen, Ling Qin, and Ella W. Yeung Muscle Physiology Laboratory, Department of Rehabilitation Sciences, Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong; Muscle Cell Function Laboratory, School of Medical Sciences and Bosch Institute, University of Sydney, New South Wales, Australia; and Musculoskeletal Research Laboratory, Department of Orthopaedics and Traumatology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong
منابع مشابه
Role of the calcium-calpain pathway in cytoskeletal damage after eccentric contractions.
The mechanism(s) underlying eccentric damage to skeletal muscle cytoskeleton remain unclear. We examined the role of Ca(2+) influx and subsequent calpain activation in eccentric damage to cytoskeletal proteins. Eccentric muscle damage was induced by stretching isolated mouse muscles by 20% of the optimal length in a series of 10 tetani. Muscle force and immunostaining of the cytoskeletal protei...
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Muscles that are stretched during contraction (eccentric contractions) show deficits in force production and a variety of structural changes, including loss of antibody staining of cytoskeletal proteins. Extracellular Ca(2+) entry and activation of calpains have been proposed as mechanisms involved in these changes. The present study used isolated mouse extensor digitorum longus (EDL) muscles s...
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